Book

© 2017

Softcover  ISBN 978-3-319-82915-9

Edition Number 1

Number of Pages XVI, 479

27 b/w illustrations, 26 illustrations in colour

Topics Pharmaceutics, Complementary and Alternative Medicine

Softcover Book

• Systematically covers major toxicities and provides an improved understanding of the hazards inherent in herbals and botanicals

• Reviews the development and implementation of predictive toxicology tools for preempting the toxicity risks of herbals

• Provides a comprehensive discussion of complex mixtures and the sophisticated tools needed to assess them?

About this book

This volume provides a comprehensive overview of the hazards inherent in herbal medicinal products, with systematic coverage of major toxicities. Topics include composition and quality control, toxicokinetics, interactions, safety pharmacology, approaches to studying complex mixtures including metabolomics and systems network pharmacology, and long-term toxicity.

The volume also discusses various organ toxicities with a special emphasis on basic mechanisms of actions and the multicomponent and multi-target nature of herbal products. It concludes with a look to future challenges and opportunities.

With contributions from noted experts, Toxicology of Herbal Products is a necessary resource for physicians, pharmacists, and toxicologists interested in complex plant-derived products.

Keywords

Genotoxicity

Herbal medicine

Metabolomics

Pharmacokinetics

Teratogenicity

Toxicity hazards

Table of contents (16 chapters)

Toxicity of Herbal Medicines: From Past to Present to Future

Werner Knöss

Pages 1-9

History and Current Status of Herbal Medicines

Jandirk Sendker, Helen Sheridan

Pages 11-27

Composition and Quality Control of Herbal Medicines

Jandirk Sendker, Helen Sheridan

Pages 29-65

Toxicokinetics of Herbal Products

Olavi Pelkonen, Jorma T. Ahokas

Pages 67-80

Interactions Between Conventional and Herbal Medicinal Products

Danielle Sevior, Jorma Ahokas

Pages 81-98

Safety Pharmacology of Herbal Products

Gert Laekeman

Pages 99-127

Systems Network Pharmaco-Toxicology in the Study of Herbal Medicines

Alessandro Buriani, Stefano Fortinguerra, Maria Carrara, Olavi Pelkonen

Pages 129-164

Metabolomics Applications in Herbal Medicine

Kati Hanhineva, Markku Pasanen

Pages 165-178

Genotoxicity and Carcinogenicity of Herbal Products

Mélanie Poivre, Amandine Nachtergael, Valérian Bunel, Okusa Ndjolo Philippe, Pierre Duez

Pages 179-215

Teratogenicity and Developmental Toxicity of Herbal Products

Ean-Jeong Seo, Thomas Efferth

Pages 217-235

Sensitization and Allergies of Herbal Products

Jacqueline Wiesner

Pages 237-269

Herbal Hepatotoxicity

Chit Shing Jackson Woo, Hani El-Nezami

Pages 271-305

Nephrotoxicity of Herbal Products

Thomas Baudoux, Joëlle L. Nortier

Pages 307-344

Herbal Neurotoxicity: An Introduction to Its Occurrence and Causes

Elizabeth M. Williamson

Pages 345-362

Cardiovascular Toxicities of Herbal Products: An Overview of Selected Compounds

Pieter van der Bijl Jr., Pieter van der Bijl Sr.

Pages 363-383

Clinical Perspectives in Diagnostic-omics and Personalized Medicine Approach to Monitor Effectiveness and Toxicity of Phytocomplexes

Alessandro Buriani, Stefano Fortinguerra, Maria Carrara

Pages 385-476

Pages 477-479

Reviews

“This comprehensive book on herbal product toxicology covers the history of herbal products to the role of systems biology in evaluating the toxicity of complex mixtures. … It is a timely and much‐needed book for beginner toxicologists. It is suitable for students, researchers, and anyone who would like to have a quick introduction to this subject. … I would recommend this book for a quick glance of this field.” (Vijaykumar P. Kale, Doody’s Book Reviews, September, 2017)

Editors and Affiliations

Department of Pharmacology & Toxicology, University of Oulu, Oulu, Finland

Olavi Pelkonen

Service de Chimie Thérapeutique et de Pharmacognosie, University of Mons, Mons, Belgium

Pierre Duez

Faculty of Pharmacy, University of Helsinki, Helsinki, Finland

Pia Maarit Vuorela, Heikki Vuorela

About the editors

Olavi Pelkonen

Professor of Pharmacology (emeritus) and Previous Head of the Department

Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland. Olavi Pelkonen has MD, PhD degree from the University of Oulu, Finland. In 1978-2010 he was Associate and Full Professor of Pharmacology as well as Head of the Department in Oulu, Finland. He has >300 original and review articles in international scientific journals, mainly on various aspects of drug and carcinogen metabolism, especially by cytochrome P450 enzymes, and their regulation by genetic and environmental factors. During the last 10 years, he was a co-opted toxicology expert at Committee of Herbal Medicinal Products of European Medicines Agency.

Pierre Duez

Professor of Pharmacognosy, Pharmacology and Nutrition and Head of the Unit

Unit of Therapeutic Chemistry and Pharmacognosy, University of Mons (UMONS), Mons, Belgium.

Pierre Duez is a Pharmacist, PhD degree from the Université Libre de Bruxelles (ULB), Belgium, holding a thesis on DNA photo-oxidative damage.

In 2002-2013, he was professor of Pharmacognosy and Bromatology, ULB.

He has 140 original and review articles in international scientific journals, mainly on various aspects of DNA damage and repair, analytical chemistry, and pharmacognosy. His major research interests concern the modulation of DNA repair mechanisms by natural products, with the development of analytical methods to probe different mechanisms of DNA repair. Since 8 years, he is member of the working group «Traditional Chinese Medicines» of the European Directorate for the Quality of Medicines & Healthcare (European Pharmacopoeia), Council of Europe.

Pia M. Vuorela

Professor of Pharmaceutical Biology and Vice Dean at Faculty of Pharmacy

University of Helsinki, Helsinki, Finland.

Pia M. Vuorela has PhD (Pharm.) degree from the University of Helsinki, Finland. In 2005-2013 she was Full Professor of Pharmaceutical Chemistry and acted as Head of Pharmacy at Åbo Akademi University in Turku, Finland, and since 2013 she conducts as a Full Professor of Pharmaceutical Biology at University of Helsinki, and is also the Vice Dean. She has Adjunct Professor ships in Pharmacognosy since 1994 in Helsinki, and in Pharmaceutical Chemistry since 2003 in Turku. She has almost 200 original and review articles in international scientific journals, mainly on bioassays, pharmaceutically relevant microbial targets (biofilms, intracellular pathogens), and lately on development of novel anti-infectives for pharmaceutically relevant formulations (medical devices).

Professor Heikki Vuorela

Professor Heikki Vuorela, Ph.D. (pharm) is professor of Pharmacognosy at the University of Helsinki (1998- present) and Vice Dean in research in the Faculty of Pharmacy (2004 – 09). He has worked also as researcher in Novartis AG (Sandoz AG), Basel and ETH-Zurich, Switzerland. Prof. Vuorela has authored over 130 peer-reviewed scientific articles and 3 patent families in pharmacy especially in the field of drug discovery and chromatography. He has been principal supervisor for 16 doctoral dissertations and has been the official opponent of 10 Ph.D and Ph.D. (pharm) examinations in Finland and Switzerland. During last years Prof. Vuorela has focused his scientific interest to natural product drug discovery.