Sepsis and Systemic Inflammatory Syndromes, An Issue of Critical Care Clinics 2026, 1st Edition /Authors: Manu Shankar-Hari,Lieuwe D. J. Bos

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Contains 13 relevant, practice-oriented topics including novel trial designs in critically ill patients; principles of drug discovery with extreme phenotypes of critical illness; non-immune host response to sepsis; AMR in sepsis; sepsis and the immunocompromised host; acute inflammation; and more.

Provides in-depth clinical reviews on sepsis and systemic inflammatory syndromes, offering actionable insights for clinical practice.

 

 

 

Descripción

 

ISBN Number9780443432804
Main AuthorManu Shankar-Hari,Lieuwe D. J. Bos
Copyright Year2026
Edition Number1
FormatBook
Trim6 x 9 mm
ImprintElsevier
Page Count240
Publication Date28 Oct 2026
Stock StatusPre-order now and your purchase will be shipped following the release on 10/28/26

 

 

In this issue of Critical Care Clinics, guest editors Drs. Manu Shankar-Hari and Lieuwe D. J. Bos bring their considerable expertise to the topic of Sepsis and Systemic Inflammatory Syndromes. Sepsis and systemic inflammatory syndromes represent life-threatening medical emergencies and remain leading causes of morbidity and mortality worldwide. Advances in early detection, biomarker development, and targeted immunomodulatory therapies continue to reshape clinical practice, making this issue especially timely for clinicians in emergency medicine, critical care, and multiple medical specialties.

Key Features

  • Contains 13 relevant, practice-oriented topics including novel trial designs in critically ill patients; principles of drug discovery with extreme phenotypes of critical illness; non-immune host response to sepsis; AMR in sepsis; sepsis and the immunocompromised host; acute inflammation; and more.

 

  • Provides in-depth clinical reviews on sepsis and systemic inflammatory syndromes, offering actionable insights for clinical practice.

 

  • Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Author Information

Manu Shankar-Hari,Centre for Inflammation Research, Institute for Repair and Regeneration, University of Edinburgh, Edinburgh, UK. Department of Critical Care, Royal Infirmary of Edinburgh, Edinburgh, UK;Lieuwe D. J. Bos,Department of Intensive Care Medicine at Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

October 2026

Volume 42Issue 4p683-908
Sepsis and Systemic Inflammatory Syndromes
Edited byShankar-Hari Manu MSc, FFICM MD, PhD, Centre for Critical Illness Research, School of Immunology & Microbial Sciences, Kings College London, London SE, UK, Bos Lieuwe D.J. MD, PhD Department of Intensive Care, Amsterdam UMC, Amsterdam, The Netherlands

Miscellaneous

  • Sepsis and Systemic Inflammatory Syndromes

    • Manu Shankar-Hari,
    • Lieuwe D.J. Bos
    Published in issue: October 2026
    i
  • Copyright

    Published in issue: October 2026
    ii
  • Contributors

    Published in issue: October 2026
    iii-vi

Contents list

  • Contents

    Published in issue: October 2026
    vii-x

Other contents

  • Forthcoming Issues

    Published in issue: October 2026
    xi

Editorial

  • Beyond Syndromic Labels: Need for Molecular Mechanistic Reframing of Sepsis and Systemic Inflammatory Syndromes for Effective Translation

    • Manu Shankar-Hari,
    • Lieuwe D.J. Bos
    Published online: June 19, 2026
    xiii-xv

Review article

Post-Sepsis Syndrome after Critical Illness

Epidemiology and Long-term Outcomes

  • Hannah Wozniak,
  • Eleonora Balzani,
  • Erminio Santangelo,
  • Margaret Herridge
Published online: June 22, 2026
p683-700

Immune-Mediated Inflammatory Diseases and the Critically Ill

  • Jason Thomas,
  • Iain McInnes,
  • Lucy McGeoch
Published online: June 25, 2026
p701-718

Early Management of Sepsis

  • Elizabeth S. Munroe,
  • Ithan D. Peltan,
  • Hallie C. Prescott
Published online: June 11, 2026
p719-743

Post-Sepsis Syndrome

From Pathogenesis Toward Novel Management Strategies

  • Daphne Schouten,
  • W. Joost Wiersinga,
  • Lonneke van Vught
Published online: June 18, 2026
p745-761

Antimicrobial Resistance in Patients with Sepsis

  • Alexandre P. Zavascki,
  • Ana C. Gales,
  • Paulo Mergulhao,
  • Andre C. Kalil
Published online: June 22, 2026
p795-820

Real-time Subgrouping of Sepsis and Systemic Inflammatory Syndromes

  • Ross McMullan,
  • Sivasubramanium V. Bhavani,
  • Pratik Sinha
Published online: June 22, 2026
p839-855

The Immunometabolic Architecture of Sepsis

Bridging Cellular Bioenergetics and Systemic Immune Dysregulation

  • Valentim Rodrigues,
  • Duarte Abecasis,
  • Luis F. Moita
Published online: June 16, 2026
p857-874

Immunosuppression in the Pathophysiology of Sepsis

  • Tristan Couwenbergh,
  • Wouter A. van der Heijden,
  • Mihai G. Netea
Published online: June 17, 2026
p875-889

Sepsis and Systemic Inflammatory Syndromes

Effects of Systemic Inflammation on the Brain

  • Mayra Romijnders,
  • Bram Snoek,
  • Luc van Oss,
  • Peter Pickkers,
  • Wilson F. Käyser-Abdo
Published online: June 19, 2026
p891-907

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