Descripción
- Discusses the mechanisms of obesity and possibilities for the development of new treatment strategies
- Includes new chapters on obesity-related epigenetic modifications and nanotechnology-based clinical approaches
- A comprehensive review of the molecular aspects of obesityrelated lipotoxiciy
About this book
This book is a comprehensive review of the recent research on the lipotoxicity-related mechanisms in obesity and the development of new treatment strategies. In this second edition, the possible molecular treatment methods and their recent clinical approaches are discussed in addition to the basic mechanisms that are available and thoroughly reviewed previously. Moreover, all chapters have been reviewed, according to the current concepts and seven new chapters are added, covering obesity-related epigenetic modifications, senescence, obesity-related cancer development, endocrine disruptors, as well as nanotechnology-based clinical approaches.
This book is an essential resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, and cardiologists, as well as all researchers or students who want to learn the mysteries of obesity.
Keywords
- Lipolysis
- Lipotoxicity
- Obesity
- Protein Kinases
- Adipose Tissue Hypoxia
- Micro RNA
- Breast cancer
- Circadian rhythm
- Fatty acid
- Non-alcoholic fatty liver disease
- Hematological disorders
- Bariatric surgery
- Melanoma
- Endothelial dysfunction
- Microbiota
- Insulin resistance
- Leptin
- Adiponectin
- Pteridine pathway
Table of contents (31 chapters)
Front Matter
Pages i-ixThe Definition and Prevalence of Obesity and Metabolic Syndrome: Correlative Clinical Evaluation Based on Phenotypes
- Atilla Engin
Pages 1-25Misalignment of Circadian Rhythms in Diet-Induced Obesity
- Atilla Engin
Pages 27-71The Checkpoints of Intestinal Fat Absorption in Obesity
- Ayse Basak Engin, Atilla Engin
Pages 73-95Lipid Storage, Lipolysis, and Lipotoxicity in Obesity
- Atilla Engin
Pages 97-129Mechanism of Obesity-Related Lipotoxicity and Clinical Perspective
- Ayse Basak Engin
Pages 131-166The Unrestrained Overeating Behavior and Clinical Perspective
- Atilla Engin
Pages 167-198Protein Kinases in Obesity, and the Kinase-Targeted Therapy
- Atilla Engin
Pages 199-229Adipose Tissue Dysfunction Determines Lipotoxicity and Triggers the Metabolic Syndrome: Current Challenges and Clinical Perspectives
- Stefania Carobbio, Vanessa Pellegrinelli, Antonio Vidal-Puig
Pages 231-272Message Transmission Between Adipocyte and Macrophage in Obesity
- Ayse Basak Engin
Pages 273-295Reappraisal of Adipose Tissue Inflammation in Obesity
- Atilla Engin
Pages 297-327Adipose Tissue Hypoxia in Obesity: Clinical Reappraisal of Hypoxia Hypothesis
- Atilla Engin
Pages 329-356Microbiota and Lipotoxicity
- Evren Doruk Engin
Pages 357-372Endoplasmic Reticulum Stress and Obesity
- Erkan Yilmaz
Pages 373-390Insulin Resistance, Obesity, and Lipotoxicity
- Dilek Yazıcı, Selin Çakmak Demir, Havva Sezer
Pages 391-430Adiponectin Resistance in Obesity: Adiponectin Leptin/Insulin Interaction
- Atilla Engin
Pages 431-462The Mechanism of Leptin Resistance in Obesity and Therapeutic Perspective
- Atilla Engin
Pages 463-487Endothelial Dysfunction in Obesity and Therapeutic Targets
- Atilla Engin
Pages 489-538Nonalcoholic Fatty Liver Disease and Staging of Hepatic Fibrosis
- Atilla Engin
Pages 539-574Lipotoxicity-Related Hematological Disorders in Obesity
- Ibrahim Celalettin Haznedaroglu, Umit Yavuz Malkan
Pages 575-594
MicroRNAs as Epigenetic Regulators of Obesity
- Ayse Basak Engin, Atilla Engin
Pages 595-627Tryptophan Metabolism in Obesity: The Indoleamine 2,3-Dioxygenase-1 Activity and Therapeutic Options
- Ayse Basak Engin, Atilla Engin
Pages 629-655Targeted Nano-Based Systems for the Anti-Obesity Agent’s Delivery
- Ayse Basak Engin, Evren Doruk Engin, Atilla Engin
Pages 657-676Clinical Perspectives, Eligibility, and Success Criteria for Bariatric/Metabolic Surgery
- Carolina M. Perdomo, Manuel F. Landecho, Víctor Valentí, Rafael Moncada, Gema Frühbeck
Pages 677-695Bariatric Surgery in Obesity: Metabolic Quality Analysis and Comparison of Surgical Options
- Atilla Engin
Pages 697-726Next-Cell Hypothesis: Mechanism of Obesity-Associated Carcinogenesis
- Ayse Basak Engin, Atilla Engin
Pages 727-766Obesity-Associated Breast Cancer: Analysis of Risk Factors and Current Clinical Evaluation
- Atilla Engin
Pages 767-819Obesity-Senescence-Breast Cancer: Clinical Presentation of a Common Unfortunate Cycle
- Ayse Basak Engin, Atilla Engin
Pages 821-850New Insights into the Link Between Melanoma and Obesity
- Monica Neagu, Elena-Georgiana Dobre
Pages 851-867Olive Oil’s Attenuating Effects on Lipotoxicity
- Maamoun Basheer, Mariana Bolus, Areej Basheer, Arraf Loai, Assy Nimer
Pages 869-882Unravelling the Influence of Endocrine-Disrupting Chemicals on Obesity Pathophysiology Pathways
- Carina Proença, Marisa Freitas, Sílvia Rocha, José Miguel P. Ferreira de Oliveira, Félix Carvalho, Eduarda Fernandes
Pages 883-918Macrophage Activation Syndrome in Coinciding Pandemics of Obesity and COVID-19: Worse than Bad
- Ayse Basak Engin, Evren Doruk Engin, Atilla Engin
Pages 919-954Back Matter
Pages 955-962
Editors and Affiliations
Faculty of Pharmacy, Department of Toxicology, Gazi University, Hipodrom, Türkiye
Ayse Basak ENGIN
Faculty of Medicine, Department of General Surgery, Gazi University, Besevler, Türkiye
Atilla ENGIN
About the editors
Bibliographic Information
- Book TitleObesity and Lipotoxicity
- Hardcover ISBN978-3-031-63656-1Published: 18 September 2024
- Softcover ISBN978-3-031-63659-2Due: 02 October 2025
- Series ISSN0065-2598
- Series E-ISSN2214-8019
- Edition Number 2
- Number of Pages IX, 962
- Number of Illustrations18 b/w illustrations, 51 illustrations in colour
- TopicsBiomedicine, general, Pharmacology/Toxicology, Endocrinology






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