Altered Metabolism: A Major Contributor of Comorbidities in Neurodegenerative Diseases Book © 2024 – Editors: Namita Agrawal

This book presents a systematic and extensive understanding about metabolic alterations affecting multiple aspects of different neurodegenerative diseases (NDDs), such as Alzheimer’s, Parkinson’s, Huntington’s disease, SCAs, SBMA, DRPLA, ALS, Freidrich Ataxia etc. The book also illustrates  cellular and molecular mechanisms behind the key  neurodegenerative diseases and further expands on concept of unique and developing biomarkers associated with the onset and progression of NDDs. Additionally, it elaborates on the concept of latest imaging tools to monitor state of NDDs and accordingly develop therapeutic approaches entailing phytochemicals in the management of metabolic alterations associated with NDDs that ultimately suppresses course of devastating NDDs. The book aids to improve the overall understanding about the NDD and involvement of metabolic disorder as a major factor for indisposition of the disease. Therefore, suggesting that targetting metabolic variations by phytochemicals can combat NDD related symptoms for the betterment of impacted patients.

While introducing cellular and molecular mechanisms and the treatment regimen under the umbrella of metabolism in several NDDs, the book covers major aspects of understanding the metabolic basis of NDDs, its implications, and treatment. This will inflate the readers’ understanding about this particular area and guide those working in this domain, be it a researcher or clinicians,to choose or design effective therapeutic strategies to curb metabolic alterations linked with these disorders. This book will not only contribute towards improving the overall state of the challenged individuals but will also bring new hope towards improving the quality of lives of affected patients.

Namita Agrawal is currently a Professor at the Department of Zoology, University of Delhi, India. Prof. Agrawal has been addressing numerous questions related to debilitating neurodegenerative diseases for past 25 years. She started working on neurodegenerative diseases at the  Department of Development and Cell Biology, University of California, Irvine, USA. Her research group at University of Delhi is  trying to comprehend the mechanistic basis of neurodegenerative diseases and its cure  by using phytochemicals. Additionally, her research interests also include understanding of various aspects involved in Cancer and  nanomaterials.Prof. Agrawal has published research papers in peer-reviewed journals like Science, PNAS, Journal of Cell Biology, Development, Developmental Biology, Nature Scientific Reports, PLOS One, J. of Huntington’s disease etc. She has recently edited and wrote several chapters in a book published by Springer entitled “Toxicology of Nanoparticles: Insights from Drosophila”. Additionally, she frequently writes chapters in the books related to neurodegenerative diseases. In addition to her dedication towards research, Dr. Agrawal has almost 15 years of experience in teaching Genetics, Cytogenetics and Developmental Biology to post-graduate students at the Department of Zoology, University of Delhi, India.